Table 4 Pharmacokinetics.
From: New chalcone derivatives as potential antimicrobial and antioxidant agent
S/N | GI absorption | BBB permeant | P-gp substrate | CYP1A2 inhibitor | CYP2C19 inhibitor | CYP2C9 inhibitor | CYP2D6 inhibitor | CYP3A4 inhibitor | Log Kp (cm/s) |
|---|---|---|---|---|---|---|---|---|---|
6a | High | Yes | No | Yes | Yes | Yes | No | No | − 5.33 |
6b | High | Yes | No | Yes | Yes | Yes | No | No | − 5.15 |
6c | High | Yes | No | Yes | Yes | Yes | Yes | No | − 4.98 |
6d | High | Yes | No | Yes | Yes | Yes | No | Yes | − 4.86 |
6e | High | Yes | No | Yes | Yes | Yes | No | Yes | − 5.50 |
6f | High | Yes | No | Yes | Yes | Yes | No | No | − 5.52 |
6g | High | Yes | No | Yes | No | Yes | No | Yes | − 5.32 |
