Table 1 Protein biomarkers which were differentially expressed after the DI.

From: A dry immersion model of microgravity modulates platelet phenotype, miRNA signature, and circulating plasma protein biomarker profile

Cardiovascular biomarker panel (protein biomarker & main function)

Inflammatory biomarker panel (protein biomarker & main function)

Adrenomedullin (ADM)

Vasodilation and regulation of hormone secretion

Axin-1 (AXIN1)

Negative regulator of the WNT signalling pathway

Dickkopf related protein-1 (DKK1)

WNT signalling pathway inhibitor

Interleukin-6 (IL6)

Pro-inflammatory cytokine

Heat shock protein-27 (HSPB1)

Stress resistance, actin organization

STAM-binding protein (STAMBP)

Cytokine-mediated signalling

Lectin like oxidised LDL receptor-1 (OLR1)

Binds, internalises, degrades oxidized LDL

Sulfotransferase 1A1 (SULTA1)

Catalyse the sulphate conjugation of hormones, neurotransmitters

NF-Kappa B essential modulator (IKBKG)

Inflammation, immune genes

SIRT2

NB: Possible role in epigenetic gene silencing

Renin (REN)

Activation of angiotensinogen pathway

Matrix metalloproteinase-10 (MMP10)

Degradation of extracellular matrix

Proto-oncogene non receptor tyrosine kinase (SRC)

Regulation of cell growth

Matrix metalloproteinase -3 (MMP3)

Degradation of extracellular matrix

Tissue plasminogen activator (PLAT)

Disintegration of blood clots

 
  1. The column on the left displays differentially expressed proteins from the CVD panel and the column on the right displays differentially expressed proteins from the inflammation panel.
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