Figure 3
(a–c) Model and motion produced by principal component analysis for wild and mutant type of CD36 in presence and absence of PLM a function of time during 100,000 ps (100 ns). (a) Principal component analysis, PC2 vs PC1, PC2 vs PC3, PC3 vs PC1 and an eigenvalue rank plot. (b) Visualization of the motions along PC1. (c) Motion of two different modes by ANM Analyze, the red arrows show the direction and amplitudes of the movements occurred from first trajectory of holo and apo form in (gray) and (pink) color respectively. (d,e) Cross-correlation Analysis matrix of the fluctuations of the C α atoms of the residue from their average during 100 ns for wild and mutant type of CD36 in presence and absence of PLM. (d) Cross-correlation map for MD simulation. Cyan color indicates a positive correlation between residue fluctuations, while the pink color depicts a negative correlation. (e) Residue cross-correlations. CD36 is depicted by gray cartoon. Red and blue lines indicate correlated and anti-correlation motions.
