Figure 3 | Scientific Reports

Figure 3

From: Protective effects of low-molecular-weight components of adipose stem cell-derived conditioned medium on dry eye syndrome in mice

Figure 3

Different size fractions of ADSC-CM showed different protective effects in the HCEC desiccation stress experiment and tear stimulation effects in the controlled-environment chamber (CEC) mice. (A) HCECs treated with fractions of molecular size < 30 kD, < 10 kD, < 3kD after desiccation showed better viability than thosed treated with > 30 kD, > 10 kD, and > 3 kD. (N = 3) *p < 0.05, **p < 0.01, ***p < 0.001 compared with the non-dry control. #p < 0.05, ##p < 0.01, ### p < 0.001 compared with the corneal epithelial cell basal medium (CEM). (N = 5) (B) In the CEC-induced dry eye study, mice reated with fractions ADSC-CM with molecular size < 10 kD or < 3kD had more tear secretion than thosed treated with > 10 kD or > 3 kD. (N = 4). *p < 0.05, **p < 0.01, *** p < 0.001, compared with Non-dry control. #p < 0.05, # # p < 0.01, # # # p < 0.001, compared with Dry control. The values were expressed as the means ± SD. (N = 5).

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