Figure 2 | Scientific Reports

Figure 2

From: An optimized 3D-printed perfusion bioreactor for homogeneous cell seeding in bone substitute scaffolds for future chairside applications

Figure 2

Bioreactor prototypes. (A) Schematic presentation of the different bioreactor types (longitudinal section). Black: shape of the perfusion chamber and the inflow/outflow nozzles. Blue: scaffold block. Red: silicone encasement around the scaffold. The perfusion chambers of type 1 and type 2 are 1 cm in width and 2 cm in height, type 3 is 2 cm in width and 1 cm in height. The presence or absence of the encasement is indicated by enc+ or enc−, respectively. (B) Design of the four bioreactors integrated in a single 3D-printed block drawn by Autocad Fusion 360. The different inlet and outlet geometries are visible above and below the scaffold chambers. Arrows indicate separate inflow and outflow lines of the chambers. Central connectors are needed for the water circulation system to regulate the temperature. Bioreactor types 2 and 3 with encasement harbor a silicone sealing (red) for the scaffolds (blue). (C) 3D view of the bioreactor without the silicon encasement.

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