Figure 1 | Scientific Reports

Figure 1

From: Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production

Figure 1

Synthesis of EGT and EgtD structure in actinobacteria. (A) Multi-step pathway in which L-Histidine is converted into EGT in M. tb. (B) Superposition of M. smegmatis EgtD in a complex with L-Histidine only (orange) and with both L-Histidine and AdoHcy (green) (PDB: 4uy6 and 4uy7). Residues interacting with L-Histidine are shown with gray carbons and those interacting with AdoMet are in green.

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