Figure 10 | Scientific Reports

Figure 10

From: Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production

Figure 10

Superposition of M. tb EgtD-Imatinib (green) and EgtD-L-Histidine (gray) structures. Highlighted are the interaction differences between the L-Histidine and Imatinib structures. In the L-Histidine complex Tyr56, Tyr206, Ser284, and Asn166 of EgtD. Tyr39 forms a van der Waals interaction with the α-carbon of L-Histidine that is lacking in the Imatinib complex.

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