Figure 11 | Scientific Reports

Figure 11

From: Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production

Figure 11

Required interactions for EgtD active site closing. (A) Super position of M. tb EgtD-TGX221 complex (green carbons) with closed M. smegmatis EgtD complex (gray carbons) (B) Super position of M. tb EgtD-SGH complex (tan carbons) with closed M. smegmatis EgtD complex (gray). The indicated polar (black dashed bonds) and non-polar interactions (green dashed bonds) are required for EgtD active site closing. Each of the interactions are lacking in both the TGX221 and SGH inhibitor complexes.

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