Figure 3
Metabolic pathway análisis based on metabolic enrichment analysis and topologic analysis of metabolomic profiles comparing metabolic pathways shifts when comparing: (a) 21 vs. 180 days in milk, or (b) North American vs. New Zealand Holstein at 21 days in milk. Increasingly red colors indicate lower P-values (more significant shift in the pathway), greater circle size indicate greater pathway impact. Numerous depict pathways with significant regulation shift: 1: Branched-chain amino acids biosynthesis, 2: branched-chain amino acids degradation, 3: phenylalanine metabolism, 4: arginine biosynthesis, 5: arginine and proline metabolism, 6: tyrosine metabolism, 7: histidine metabolism, 8: alanine, aspartate and glutamate metabolism, 9: \(\beta \)-Alanine metabolism, 10: glycine, serine and threonine metabolism, 11: cysteine and methionine metabolism, 12:tryptophan metabolism, 13: lysine degradation, 14: phenylalanine, tyrosine and tryptophan biosynthesis, 15: aminoacyl-tRNA biosynthesis, 16: taurine and hypotaurine metabolism, 17: thiamine metabolism, 18: glutamine and glutamate metabolism, 19: nitrogen metabolism, 20: glyoxylate and dicarboxylate metabolism, 21: fructose and mannose metabolism, 22: galactose metabolism, 23: pentose and glucuronate interconversions, 24: amino sugar and nucleotide sugar metabolism, 25: citrate cycle, 26: propanoate metabolism, 27: butanoate metabolism, 28: ubiquinone and other terpenoid-quinone biosynthesis, 29: biotin metabolism, 30: glycolysis/gluconeogénesis, 31: synthesis and degradation of ketone bodies, 32: pentose phosphate pathway, 33: porphyrin and chlorophyll metabolism, 34: fatty acid biosynthesis, 35: arachidonic acid metabolism, 36: fatty acid elongation, 37: linoleic acid metabolism, 38: biosynthesis of unsaturated fatty acids, 39: fatty acid degradation, 40: primary bile acid biosynthesis, 41: glycerolipid metabolism, 42: inositol phosphate metabolism, 42: purine metabolism, 43: glutathione metabolism, 44: ascorbate and aldarate metabolism, 45: pantothenate and CoA biosynthesis, 46: hisitidine metabolism, 47: selenocompound metabolism.
