Figure 4

Main metabolic pathways identified to be differentially regulated at early vs. mid lactation stage (21 vs. 180 days in milk) according to metabolic pathways analysis performed on blood plasma metabolomic data of multiparous Holstein cows under grazing conditions. Colored circles depict effectively measured compound, while gray circles correspond to undetected ones. Negative and positive fold changes for each metabolite when comparing 21 vs. 180 days in milk are denoted by blue or red circles, respectively. Color background group metabolic pathways indicated in the figure legend, as well as significance levels.