Table 7 Demographic data of three groups classified by Urinary Cystatin-C concentration.
Group | Zero CysC (A) | Normal CysC (B) | High CysC (C) | p valuea A vs B | p valuea B vs C |
|---|---|---|---|---|---|
Cystatin-C (μg/g Cre) | < LOQb | LOQ-70 | > 70 | ||
N | 7 | 78 | 7 | ||
Male/female | 1/6 | 32/46 | 6/1 | 0.16 | 0.022 |
CKDs | 0 | 10 (7/3) | 5 (4/1) | 0.31 | 0.0001 |
Families | 1 (0/1) | 14 (4/10) | 0 | ||
Neighbors | 6 (1/5) | 54 (21/33) | 2 (2/0) | ||
Age (mean ± SD) | 36.3 ± 15.3 | 41.9 ± 17.6 | 61.1 ± 10.2 | 0.45 | 0.004 |
UACR > 30 | 0% | 1.3% | 28.6% | 0.76 | < 0.001 |
Urine blood positive | 71.4% | 43.6% | 57.1% | 0.17 | 0.49 |
Urine pH (mean ± SD) | 5.57 ± 0.67 | 5.72 ± 0.55 | 5.80 ± 0.45 | 0.50 | 0.76 |
Urine Creatinine | |||||
(mean ± SD, mg/dL) | 18.7 ± 8.1 | 105.2 ± 68.4 | 74.4 ± 44.9 | 0.0013 | 0.25 |
Urine L-FABP | |||||
(mean ± SD, μg/g Cre) | 4.72 ± 4.91 | 1.99 ± 3.08 | 65.9 ± 54.1 | 0.056 | < 0.0001 |
Low Urine volume (self-reported) | 14.3% | 25.6% | 28.6% | 0.50 | 0.87 |
High urine volume (self-reported) | 28.6% | 41.0% | 57.1% | 0.52 | 0.41 |
Estimated pathology | |||||
Glomerular damage | No | No | Yes | ||
Proximal tubule reabsorption | Conserved | Conserved | Impaired | ||
Proximal tubule damage | Likely | Not likely | Highly damaged | ||
Distal tubule reabsorption | Impaired | Conserved | Impaired | ||
Differential diagnosis | |||||
CKDu | Not likely | Not likely | Likely | ||
Other CKD | Not likely | Not likely | Possibly | ||
Tubulointerstitial nephritis | Likely | Not likely | Possibly | ||
