Figure 1
From: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Construction of a “reference” T1D co-expression network enabled the exploration of changes of gene network dynamics across time, sex and disease status. (1) TEDDY transcriptomic profiles were grouped based on time from diagnosis and a “reference” WGCNA network was constructed for cases sampled approximately 180 days before T1D diagnosis. (2) Reference network modules were tested for enrichment of GWAS implicated genes. (3) For modules identified in step 2, we evaluated longitudinal differences in connectivity between cases and controls, (4) and we investigated the role of individual genes module behavior and T1D.
