Figure 3
From: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Characterization of the TEDDY blood co-expression network. (A) Modules enriched for T1D GWAS-implicated genes (adjusted using FDR method). (B, C) GO term and pathway enrichment based on ConsensusPathDB15. The P values are FDR adjusted P values. (D–G) All enrichment P values are adjusted based on FDR method (D) Percentage of context dependent signature genes found in modules based on proxy genes identified by Zhernakova et al.16 (E) Percentage of genes differentially expressed under viral infection identified by Zaas et al.17 (F) Percentage of genes differentially expressed between EBV + and EBV- Ramos B cells18 (G) Percentage of genes found in the IRF7-driven inflammation network based on Heinig et al.9 (H–K) Ratio of expression in cases versus controls over time for cell type proxy genes (L, M) Ratio of expression in cases versus controls of viral infection signature genes .
