Figure 5
From: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Assessing gene connectivity in Blue and Purple module. (A–D) Gene connectivity (GC) over time. Red: cases, blue: controls. Genes were ranked based on variance in connectivity (based on standard deviation over time). Upper plot shows the upper 5 percent of genes based on GC for cases and controls. Lower plot shows genes of the lower 5 percentile of genes based on GC in cases and controls. (E–H) Density function of the standard deviation of the GC over time. We observed a shift to the right in cases (red line) compared to controls (blue line) that was more profound in females (E, F) than males (G, H). (C) Rank order correlation (Spearman correlation) of GC at the MDC peak between females (I) and males (J). Red dots show the top 100 differential hub genes.
