Table 1 Top 10 differentially connected genes for blue and purple modules.
From: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Module | DCG (ordered by rank) | Infection/cell type signature gene* | Differential connectivity (peak) females | Differential connectivity (peak) males | Differential connectivity p value (MDC peak) females | Differential connectivity p value (MDC peak) males |
|---|---|---|---|---|---|---|
Blue | TLR8 | 3.65 | 5.18 | 0.02 | 0.01 | |
KCNJ15 | Neutrophils | 3.89 | 6.76 | 0.02 | 0.02 | |
FCGR2A | 3.09 | 4.97 | 0.04 | 0.05 | ||
BEST1 | Neutrophils | 3.99 | 3.34 | 0.04 | 0.07 | |
UBR2 | 5.29 | 5.67 | 0.03 | 0.03 | ||
ALPK1 | 3.14 | 4.54 | 0.05 | 0.03 | ||
PGCP | 6.62 | 4.27 | 0.01 | 0.05 | ||
FPR2 | 4.92 | 3.75 | 0.02 | 0.03 | ||
PLBD1 | 7.76 | 6.34 | 3 × 10–3 | 0.02 | ||
MXD1 | Neutrophils | 2.81 | 3.25 | 0.05 | 0.03 | |
Purple | SAMD9 | 16.52 | 3.76 | 6 × 10–3 | 0.06 | |
MX2 | 9.90 | 6.52 | 0.03 | 0.04 | ||
CMPK2 | Monocytes | 14.12 | 7.56 | 0.04 | 0.03 | |
SIGLEC1 | Infection | 1726.99 | 12.76 | 2 × 10–3 | 0.03 | |
USP18 | 30.03 | 8.99 | 2 × 10–3 | 0.04 | ||
IFIH1 | 15.25 | 3.47 | 6 × 10–3 | 0.06 | ||
DDX58 | Infection | 8.46 | 9.08 | 0.03 | 0.02 | |
OASL | Infection | 8.30 | 4.37 | 0.13 | 0.05 | |
CXCL10 | Infection | 37.82 | 11.90 | 9 × 10–3 | 0.04 | |
USP41 | 1738.34 | 16.86 | < 1 × 10–4 | 0.06 |
