Table 3 Correlations between the evaluated variables and disease activity or severity in MS.

From: White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments

 

Numbers of T2 hyperintense brain lesions

The EDSS score after 1 year from the hemogram

Age

rho =  + 0.301 (p = 0.0166)

rho =  + 0.397 (p = 0.0012)

Onset phenotype with optic neuritis

rho = 0.052 (p = 0.6832)

rho = − 0.298 (p = 0.0169)

Onset phenotype with acute myelitis

rho = − 0.115 (p = 0.3704)

rho =  + 0.441 (p = 0.0003)

Total WBC count

rho = − 0.018 (p = 0.8886)

rho = − 0.006 (p = 0.9622)

RBC count

rho = − 0.225 (p = 0.0762)

rho = − 0.094 (p = 0.4622)

Platelet count

rho =  + 0.147 (p = 0.2496)

rho =  + 0.141 (p = 0.2670)

Monocyte count

rho = − 0.090 (p = 0.4850)

rho = − 0.098 (p = 0.4412)

Lymphocyte count

rho = − 0.096 (p = 0.4550)

rho = − 0.053 (p = 0.6751)

Eosinophil count

rho = − 0.447 (p = 0.0002)

rho = − 0.120 (p = 0.3470)

Basophil count

rho =  + 0.074 (p = 0.5635)

rho =  + 0.039 (p = 0.7570)

Neutrophil count

rho =  + 0.077 (p = 0.5475)

rho =  + 0.027 (p = 0.8339)

PLR

rho =  + 0.143 (p = 0.2648)

rho =  + 0.160 (p = 0.2081)

MLR

rho = − 0.027 (p = 0.8335)

rho = − 0.005 (p = 0.9689)

NLR

rho =  + 0.095 (p = 0.4598)

rho =  + 0.042 (p = 0.7393)

CSF cell count

rho = − 0.043 (p = 0.7523)

rho = − 0.094 (p = 0.4924)

OCB positivity

rho =  + 0.132 (p = 0.3335)

rho =  + 0.120 (p = 0.3760)

IgG-index

rho =  + 0.197 (p = 0.1585)

rho =  + 0.249 (p = 0.0721)

QAlb

rho = − 0.009 (p = 0.9509)

rho =  + 0.219 (p = 0.1234)

QIgG

rho =  + 0.087 (p = 0.5425)

rho =  + 0.318 (p = 0.0228)

  1. Spearman’s correlation coefficients (rho) and the p values of the test of no correlation between the clinical manifestations and laboratory test data in MS are shown.
  2. CSF, cerebrospinal fluid; EDSS, Kurtzke Expanded Disability Status Scale; IgG, immunoglobulin G; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; OCB, oligoclonal bands; PLR, platelet-to-lymphocyte ratio; QAlb, quotient of albumin; QIgG, quotient of immunoglobulin G; RBC, red blood cell; WBC, white blood cell.
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