Table 3 Univariate and multivariate analysis of factors associated with the final composite outcome (requirement of endotracheal intubation or death by COVID19).

From: Comparison of ROX and HACOR scales to predict high-flow nasal cannula failure in patients with SARS-CoV-2 pneumonia

Predictors

Univariate analysis

Multivariate analysis

Odds ratios

CI

p

Odds ratios

CI

p

ROX Index

0.86

0.76–0.98

0.025

0.99

0.90–1.09

0.947

HACOR

1.33

1.10–1.63

0.004

1.43

1.25–1.67

< 0.001

Sex male

2.37

1.10–5.27

0.031

   

Age

1.03

0.99–1.06

0.108

   

BMI†

1.04

0.96–1.12

0.367

   

Atrial fibrillation

3.70

0.73–29.34

0.151

   

CKD

4.61

1.25–21.11

0.032

3.90

1.24–15.19

0.029

Hypertension

2.01

0.97–4.25

0.063

2.46

1.29–4.81

0.007

COPD

0.37

0.13–0.98

0.047

   

pH before HFNC

11.00

0.00–70,685.37

0.589

   

PaO2 before HFNC

1.01

1.00–1.03

0.183

   

PaCO2 before HFNC

0.95

0.88–1.02

0.173

0.93

0.88–0.98

0.005

PaO2/Fio2 before HFNC

1.00

0.99–1.01

0.750

   

Glasgow coma scorea

0.63

0.30–1.17

0.175

   

Heart rateb

1.01

0.99–1.04

0.301

   

Respiratory rateb

1.15

1.05–1.27

0.002

1.14

1.05–1.23

0.001

Observations

230

230

    

R2 Tjur

0.344

0.285

    
  1. There were no significant differences (p < 0.05) between the study groups.
  2. BMI body mass index, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, HFNC high-flow nasal cannula, SaO2 blood–oxygen saturation, PaO2 arterial partial pressure of oxygen, PaCO2 partial pressure of carbon dioxide, Fio2 fraction of inspired oxygen.
  3. aBefore introduction of HFNC.
  4. b2 h post HFNC.
  5. †The body-mass index is the weight in kilograms divided by the square of the height in meters.
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