Table 1 SUV values and tumor-to-organ ratios (liver, blood and muscle) for different PCa tumor cell lines with varying PSMA expression levels: PC-3 (no PSMA expression), 22Rv1 (low PSMA expression) and C4-2 (high PSMA expression).

From: Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer

Cell line

Expression levela

SUVmean

SUVmax

Tumor-to-liver ratio

Tumor-to-blood ratiob

Tumor-to-muscle ratio

PC-3

0

0.09 ± 0.02**

0.22 ± 0.05**

1.38 ± 0.33**

1.41 ± 0.07**

2.26 ± 0.48**

22Rv1

0.94 ± 0.21

0.46 ± 0.11****

1.03 ± 0.23****

6.26 ± 1.41****

6.93 ± 1.49****

6.64 ± 3.81****

C4-2

16.36 ± 3.05

1.48 ± 0.47

3.27 ± 1.07

17.32 ± 3.55

15.47 ± 2.32

19.64 ± 5.37

  1. P values were calculated using the Wilcoxon signed-rank test with Holm correction with C4-2 as a reference, the significance level was set at p = 0.05, **p < 0.01, ****p < 0.0001.
  2. aExpression levels were determined by semi-quantitative western blot analysis and are expressed β-actin normalized density.
  3. bActivity in blood was determined by delineation of the heart.
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