Table 1 List of differentially-regulated phosphorylated protein in Ahr+/+ (WT) and Ahr−/− (KO) MLFs identified using MS.
From: Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts
Protein | Gene | Phosphorylated site(s) | Ratio: KO/WT | Functions |
|---|---|---|---|---|
Fibrillin-1 | Fbn1 | [S2704] | 2.817 | Metal ion binding; ECM structural constituent; hormone activity regulation; a cell adhesion mediator |
LIM and calponin homology domains-containing protein 1 | Limch1 | [S560] | 2.178 | Metal ion binding; actin binding; actin stress fibers assembly; focal adhesion stabilization; inhibition of cell migration |
TBC1 domain family member 15 | Tbc1d15 | [S32; S201; S203; S205; S616] | 1.912 | Regulation of intracellular protein trafficking; acting as a GTPase activating protein for Rab family proteins |
Phospholipase A2 | Pla2g4a | [S429] | 1.825 | Ca2+-dependent phospholipase and lysophospholipase activities; membrane lipid remodeling and biosynthesis of lipid inflammatory mediators |
SH3 domain-containing kinase-binding protein 1 | Sh3kbp1 | [S274; S631; S633] | 1.81 | Regulation of diverse signal transduction pathways; apoptosis; endocytosis; ubiquitin protein ligase binding; cell migration and cytoskeletal organization |
Actin filament-associated protein 1 | Afap1 | [S669] | 1.76 | Regulation of cytoskeleton organization; an adapter molecule linking other proteins to the actin cytoskeleton |
ATP-binding cassette sub-family F member 1 | Abcf1 | [S194] | 1.753 | mRNA translation initiation mediator; ATP binding and ATPase activity; RNA binding; ribosome binding |
Fibronectin | Fn1 | [S2294] | 1.748 | Regulation of cell shape, adhesion and migration; ECM organization; regulation of focal adhesion signaling |
Plexin domain-containing protein 2 | Plxdc2 | [S456] | 0.549 | Transmembrane protein; Regulation of tumor angiogenesis |
Neurogenic locus notch homolog protein 2 | Notch2 | [S2082] | 0.519 | Transmembrane receptor for membrane-bound ligands; transcriptional regulator; regulation of cell differentiation, proliferation and apoptotic programs |
CYFIP-related Rac1 interactor B | Cyrib | 0.508 | Regulation of mitochondrial function; attenuation of actin filament polymerization, phagocytosis and cell migration; protection against infection | |
Filamin A-interacting protein 1-like | Filip1l | [S789; T992] | 0.366 | Antiangiogenic; negative regulation of proliferation and migration; positive regulation of apoptosis |
STIP1 homology and U box-containing protein 1 | Stub1 | [S20] | 0.221 | Quality control for misfolded or incompletely synthesized proteins; modulation of the activity of several chaperone complexes; regulation of protein ubiquitination |
