Table 2 Operative and pathologic findings. DRM, distal resection margin.

From: Impact of the distal resection margin on local recurrence after neoadjuvant chemoradiation and rectal excision for locally advanced rectal cancer

 

DRM ≥ 1 cm (n = 418)

DRM < 1 cm (n = 89)

P

Type of operation

  

 < 0.001

LAR

286 (68.4%)

35 (39.3%)

 

ISR

105 (25.1%)

54 (60.7%)

 

APR

27 (6.5%)

-

 

LPND

72 (17.2%)

11 (12.4%)

0.33

Tumor size, cm

3.2 (2.0–4.5)

2.5 (1.8–3.3)

 < 0.001

Lymphovascular invasion

32 (7.7%)

3 (3.4%)

0.22

Venous invasion

32 (7.7%)

4 (4.5%)

0.41

Tumor perforation

9 (2.2%)

2 (2.2%)

1.00

Pathologic stage

  

 < 0.001

ypT0N0

45 (10.8%)

21 (23.6%)

 

ypT0N + 

6 (1.4%)

-

 

I

60 (14.4%)

24 (27.0%)

 

II

147 (35.2%)

30 (33.7%)

 

III

160 (38.3%)

14 (15.7%)

 

CRM, positive (≤ 1 mm)

40 (9.6%)

8 (9.0%)

1.00

Pathologic LPN positive

23/72 (31.9%)

2/11 (18.2%)

0.57

Tumor regression grade

  

0.002

0 (no regression)

6 (1.5%)

2 (2.3%)

 

1 (minor regression)

52 (12.9%)

8 (9.2%)

 

2 (moderate regression)

144 (35.8%)

15 (17.2%)

 

3 (good regression)

149 (37.1%)

41 (47.1%)

 

4 (total regression)

51 (12.7%)

21 (24.1%)

 
  1. LAR low anterior resection, ISR intersphincteric resection, APR abdominoperineal resection, LPND lateral pelvic lymph node dissection, CRM circumferential resection margin, LPN lateral pelvic lymph node.
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