Figure 4

Comparison of in vitro, quail egg ex ovo xenograft and mouse in vivo xenograft results. (a,b) In vitro drug curves, each point has n = 4 replicates. (c,d) For the ex ovo drug curves, each concentration has n = 4–6 replicates. (e) The murine xenograft survival analyses for HB243 (n = 4) defined an event occurrence as tumor volume equal or greater than 0.75 cc, and a significant difference observed between treatment and control groups with a p = 0.031 using the Mantel-Cox test. (f) The survival of HepG2 bearing mice (n = 3) using the same criteria did not have a difference between treatment and control groups with p = 0.685. (g) Shown is the experiment timeline for drug dosing in mouse xenograft studies.