Figure 1 | Scientific Reports

Figure 1

From: Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia

Figure 1

Experimental timelines. (A) Timeline for the animal study. All experiments were completed 17–19 days after C26 cell inoculation, when mice had significant weight loss and muscle wasting. (B) Langendorff protocol. Hearts were mounted and equilibrated, and baseline pacing data were collected at 7 Hz. A subset of hearts underwent a stepped pacing stress protocol, with a pacing increase of 1 Hz every 30–60 s up to 12 Hz. Hearts were then re-equilibrated at 7 Hz to conclude the experiment.

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