Figure 2

Gene amplification analysis of cancer-related genes. Gene amplification of 26 cancer-related genes was evaluated by utilizing reading depth of individual genes. For an individual sample, reading depths of 160 amplicons were plotted in a panel. Each amplicon was expected to be on a regression line calculated from all amplicons, but amplicons of the amplified gene were outlying. ERBB2 was amplified in 3 gastric cancers; KRAS was amplified in 2 cancers; and PIK3CA and MET were amplified in one cancer. Open circles show the amplicon of amplified genes. Black circles show that of all the other genes.