Table 1 List of somatic mutations in the 55 gastric cancers with current H. pylori infection.

From: Comparable genetic alteration profiles between gastric cancers with current and past Helicobacter pylori infection

Sample

Gene

Coverage

Variant allele frequency

Nucleotide change

Amino acid change

B-GC1

TP53

3157

30.6

c.818G>A

p.Arg273His

B-GC3

SMAD4

9192

13.2

c.1525T>G

p.Trp509Gly

TP53

4942

30.3

c.857A>T

p.Glu286Val

B-GC8

No mutation

    

B-GC11

No mutation

    

B-GC12

No mutation

    

B-GC14

No mutation

    

B-GC15

CTNNB1a

4389

79.7

c.101G>A

p.Gly34Glu

B-GC16

TP53

5638

31.6

c.818G>A

p.Arg273His

B-GC17

NRAS

5643

29.2

c.34G>T

p.Gly12Cys

FBXW7

6577

28.4

c.1514G>A

p.Arg505His

FBXW7

4646

21.9

c.1394G>A

p.Arg465His

B-GC19

TP53

6252

14.8

c.818G>A

p.Arg273His

B-GC22

TP53

5911

38.0

c.844C>T

p.Arg282Trp

B-GC23

No mutation

    

B-GC27

ERBB4

9636

25.1

c.1817A>G

p.Lys606Arg

B-GC33

TP53

4987

63.1

c.743G>A

p.Arg248Gln

B-GC34

No mutation

    

B-GC35

No mutation

    

B-GC37

No mutation

    

B-GC38

No mutation

    

B-GC39

No mutation

    

B-GC52

No mutation

    

B-GC56

No mutation

    

B-GC63

SMAD4

1269

34.8

c.1082G>A

p.Arg361His

B-GC64

No mutation

    

B-GC66

PIK3CAa

618

15.7

c.1624G>A

p.Glu542Lys

KRASa,b

336

22.3

c.34G>A

p.Gly12Ser

KRASa,b

333

18.0

c.35G>A

p.Gly12Asp

B-GC70

No mutation

    

B-GC71

TP53

1066

66.8

c.659A>G

p.Tyr220Cys

B-GC73

No mutation

    

B-GC74

TP53

1520

55.6

c.853G>A

p.Glu285Lys

B-GC75

TP53

602

51.3

c.536A>G

p.His179Arg

B-GC77

TP53

566

43.8

c.404G>A

p.Cys135Tyr

B-GC80

TP53

546

43.4

c.536A>G

p.His179Arg

FBXW7

1063

46.8

c.1393C>T

p.Arg465Cys

B-GC81

No mutation

    

B-GC83

GNAS

222

12.6

c.2531G>A

p.Arg844His

B-GC85

No mutation

    

B-GC86

TP53

1664

59.1

c.818G>T

p.Arg273Leu

B-GC87

TP53

569

31.6

c.388C>G

p.Leu130Val

B-GC88

TP53

675

52.6

c.524G>A

p.Arg175His

ERBB4

988

53.7

c.719G>A

p.Gly240Glu

B-GC90

TP53

1833

20.7

c.818G>A

p.Arg273His

B-GC92

No mutation

    

B-GC95

No mutation

    

B-GC96

PIK3CAa

806

12.3

c.1633G>A

p.Glu545Lys

B-GC97

No mutation

    

B-GC98

No mutation

    

S2

TP53

496

34.1

c.581T>G

p.Leu194Arg

S4

TP53

438

74.2

c.581T>G

p.Leu194Arg

S13

TP53

70

15.7

c.478A>G

p.Met160Val

ERBB2a

482

23.9

c.2264T>C

p.Leu755Ser

S17

No mutation

    

S19

No mutation

    

S20

No mutation

    

S21

No mutation

    

S22

No mutation

    

S23

TP53

565

67.8

c.537T>A

p.His179Gln

S36

TP53

1142

34.9

c.524G>A

p.Arg175His

S43

TP53

239

74.9

c.1024C>T

p.Arg342Ter

S124

No mutation

    
  1. aActivated oncogene mutation.
  2. bThese mutations did not exist on the same allele.
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