Table 5 Mean ± SD of serum and urinary biochemistry findings in bitches with mammary carcinoma treated (TG) or not treated (CG) with 4.4 mg/kg/day of carprofen for 90 days and evaluated for 6 months.

From: Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen

Variable

Moment

CG

TG

P-Group

P-Moment

P-Interaction

CREA (mg/dL)

M0

0.95 ± 0.50

0.95 ± 0.21

0.9367

0.7068

0.9897

M1

0.95 ± 0.28

1.00 ± 0.24

M2

0.91 ± 0.24

0.93 ± 0.25

M3

0.89 ± 0.33

0.93 ± 0.17

M4

0.97 ± 0.33

0.89 ± 0.20

M5

0.97 ± 0.30

0.86 ± 0.25

M6

0.77 ± 0.23

0.78 ± 0.29

UREA (mg/dL)

M0

31.2 ± 16.9

26.5 ± 4.95

0.1629

0.2078

0.6425

M1

31.2 ± 9.62

34.9 ± 10.6

M2

33.5 ± 11.5

43.13 ± 3

M3

38.6 ± 14.2

35.7 ± 10.6

M4

32.8 ± 8.13

36.4 ± 7.16

M5

28 ± 5.74

32.6 ± 10.6

M6

28.2 ± 9.26

31.6 ± 6.92

ALT (U/L)

M0

42.3 ± 30.5ª

61.5 ± 53b

0.0272*

0.7279

0.9789

M1

39.6 ± 18.5ª

50.5 ± 36.5b

M2

39.2 ± 16.0a

52.6 ± 33.1b

M3

43.9 ± 18.9ª

61 ± 30.6b

M4

33.2 ± 6.94ª

48.1 ± 21.7b

M5

38.2 ± 23.4ª

45.2 ± 26.3b

M6

37.6 ± 19.5ª

37.3 ± 13.2b

DEND

M0

1034 ± 19

1012 ± 3.54

0.9319

0.9768

0.1321

M1

1028 ± 7.78

1027 ± 11.7

M2

1023 ± 9.75

1033 ± 15.1

M3

1031 ± 11.9

1027 ± 11

M4

1030 ± 11.6

1032 ± 13.1

M5

1030 ± 11.2

1025 ± 13.2

M6

1026 ± 11.9

1032 ± 12.9

Ph

M0

6.16 ± 0.87

5.75 ± 1.06

0.3356

0.0921

0.754

M1

6.68 ± 1.48

5.96 ± 0.80

M2

7.04 ± 1.44

6.5 ± 1.28

M3

6.40 ± 1.2

6.5 ± 1.16

M4

6.75 ± 1.25

6.78 ± 1.15

M5

5.3 ± 0.44

5.9 ± 0.89

M6

5.8 ± 0.83

5.91 ± 1.42

UPC

M0

0.55 ± 0.73

0.08 ± 0.05

0.2112

0.9103

0.9212

M1

0.37 ± 0.56

0.28 ± 0.33

M2

0.36 ± 0.54

0.49 ± 0.90

M3

0.50 ± 0.69

0.24 ± 0.14

M4

0.66 ± 1.01

0.35 ± 0.57

M5

0.24 ± 0.30

0.13 ± 0.10

M6

0.39 ± 0.47

0.32 ± 0.39

  1. CREA: creatinine; URA: urea; ALT: alanine aminotransferase; DEND: urine density; Ph: potential of hydrogen; UPC: urine protein/creatinine ratio.
  2. a and b indicates difference statistic.