Figure 5
From: Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload
The role of Lats2 in mediating p53 in the heart during pressure overload. Non-transgenic (NTG) and Lats2 +/- mice were subjected to either transverse aortic constriction (TAC) or sham operation for 4 weeks. (A), The levels of p53 and GAPDH were evaluated with immunoblot analyses. Representative images (left) and quantification (right) are shown. *p < 0.05 versus NTG mouse hearts with sham operation. #p < 0.05 versus NTG mouse hearts with TAC for 4 weeks. (B), The level of p53 in the heart was evaluated by immunostaining with anti-p53 antibody and anti-troponin-T antibody, the latter of which identifies cardiomyocytes. Representative images are shown.
