Figure 5 | Scientific Reports

Figure 5

From: Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

Figure 5

Generation of undirected, weighted transcriptional regulatory network from thymic NKT cell subsets. (A) Representative histograms and dot plot displaying proportion of BrdU positive cells among DP T (P1), DP NKT (P2), CD4 NKT (P3) and DN NKT (P4) cells compared to a non-injected control (NC). (B) Heat map of endogenous TCR alpha chain loci expression determined by microarray of the four different cell types across the three transitions as visualised in Cytoscape 3.8.0 (https://github.com/cytoscape/). (C) Expression profiles of genes associated with the cell cycle and cell division. Gene expression as determined by microarray (top row; n = 7/grp) and confirmed by qPCR on an independent cohort (bottom row; n = 7/grp).

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