Figure 1
From: Machine learning to estimate the local quality of protein crystal structures
Challenges at low resolution. (a) Part of CDK2 structure at high resolution (left; PDB:6Q4G) and low resolution (right; PDB:5UQ1). Atom coordinates and electron density (2mFo-DFc or ρobs) calculated from the coordinates and experimental diffraction data are shown. Although they are almost identical, the hydrogen-bonding network, including water molecules, observed at high resolution is unknown at low resolution. Parts such as side chains that cannot be determined by electron density are often transplanted from high-resolution structure. (b) Resolution distribution of structures deposited in the Protein Data Bank (11).
