Table 2 mRNA expression of Fas, Mki67, Mct8, Lat4, Met, and Lgals3 in the thyroid of cervically X-irradiated rats.
Group | Apoptosis/proliferation | Differentiation markers | PTC markers | |||
|---|---|---|---|---|---|---|
Fas | Mki67(Ki-67) | Mct8 | Lat4 | Met | Lgals3 | |
Experiment 1 | ||||||
Control | 35 ± 4.0 | 62 ± 14.4 | 18 ± 2.1 | 14 ± 2.0 | 11 ± 0.9 | 40 ± 12.1 |
1w1.5 Gy | 38 ± 1.8 | 48 ± 2.9 | 22 ± 1.7 | 11 ± 1.9 | 11 ± 0.7 | 27 ± 1.9 |
1w3Gy | 60 ± 9.0 | 85 ± 14 | 17 ± 1.3 | 7.9 ± 1.3* | 10 ± 0.6 | 56 ± 10.3 |
1w6Gy | 52 ± 4.5* | 60 ± 5.0 | 18 ± 2.1 | 7.8 ± 1.2* | 11 ± 0.9 | 42 ± 5.4 |
1w12Gy | 121 ± 9.8** | 99 ± 17 | 12 ± 0.8* | 3.9 ± 0.5** | 11 ± 0.8 | 79 ± 13.3* |
Experiment 2 | ||||||
Control | 28 ± 1.0 | 31 ± 2.1 | 17 ± 1.0 | 19 ± 3.6 | 10 ± 1.0 | 26 ± 2.3 |
1w12Gy | 51 ± 2.0** | 28 ± 1.9 | 13 ± 0.7* | 6.1 ± 0.9* | 8.5 ± 0.5 | 33 ± 3.1 |
2w12Gy | 36 ± 4.7 | 27 ± 4.5 | 17 ± 1.5 | 10 ± 1.5 | 8.6 ± 0.4 | 24 ± 1.8 |
4w12Gy | 63 ± 12 | 35 ± 3.1 | 11 ± 1.6* | 9.3 ± 2.4 | 9.1 ± 0.8 | 42 ± 6.7 |
8w12Gy | 29 ± 2.6 | 33 ± 3.4 | 18 ± 1.5 | 21 ± 3.6 | 8.7 ± 0.4 | 44 ± 6.6* |
Experiment 3 | ||||||
Control | 4.6 ± 0.9 | 15 ± 1.3 | 29 ± 5.1 | 40 ± 6.9 | 5.8 ± 0.5 | 23 ± 2.8 |
1w12Gy | 14 ± 1.2** | 18 ± 0.3 | 38 ± 7.4 | 23 ± 3.5* | 7.9 ± 0.7 | 52 ± 11.0 |
IDD | 21 ± 2.5** | 29 ± 2.7** | 18 ± 2.6** | 10 ± 1.9** | 14 ± 1.1** | 48 ± 5.1* |
1w12Gy-IDD | 21 ± 2.5** | 28 ± 2.4** | 19 ± 1.7** | 8.7 ± 0.6** | 17 ± 1.8** | 64 ± 6.6** |
