Table 5 Uni- and multivariate Cox-proportional hazard regression analyses of predictors of the development of thrombotic events in patients with SLE.

From: Risk factors for thrombotic events in Korean patients with systemic lupus erythematosus

Variables

Univariate analysis

Model 1a

Model 2b

HR

P-value

HR

P-value

HR

P-value

Hypertension

3.938 (1.527–10.154)

0.005

2.857 (1.247–6.547)

0.013

7.805 (1.929–31.581)

0.004

Anti-phospholipid syndrome

9.828 (3.798–25.434)

 < 0.001

7.291 (2.868–18.536)

 < 0.001

12.600 (4.305–36.292)

 < 0.001

Mean daily prednisolone > 5 mg/day

14.255 (5.161–39.377)

 < 0.001

9.039 (3.455–23.646)

 < 0.001

3.666 (1.318–10.197)

0.013

ACEi or ARB

2.344 (0.988–5.565)

0.053

2.002 (0.925–4.334)

0.078

0.159 (0.043–0.594)

0.006

SDIc

1.997 (1.463–2.725)

 < 0.001

1.980 (1.512–2.592)

 < 0.001

1.992 (1.465–2.709)

 < 0.001

  1. ACEi, angiotensin-converting enzyme inhibitor; aPL, anti-phospholipid antibody; ARB, angiotensin receptor blocker; HR, hazard ratio; SDI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index; SLE, systemic lupus erythematosus.
  2. aMultivariate Cox-proportional hazard regression analysis adjusted for age, gender and disease duration.
  3. bMultivariate Cox-proportional hazard regression analysis adjusted for age, gender, and disease duration, and variables significant at P < 0.10 in univariate analyses, including hypertension, central nervous system involvement, proteinuria, anti-phospholipid antibody, total cholesterol, anti-phospholipid syndrome, mean daily prednisolone > 5 mg/day, anticoagulation or antiplatelet drugs, ACEi or ARB and SDI.
  4. cSDI was measured before the occurrence of thrombotic events or at the last visit.
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