Figure 2 | Scientific Reports

Figure 2

From: Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats

Figure 2

Body temperature. (A) Male temperature: Data are presented as mean ± SEM; n = 5–6 for each group. Presence of (*) with a solid and dashed green line indicates that THC-INH and THC-INJ respectively differ from one or more other groups. THC-INH resulted in immediate hypothermia at 30-min (THC-INH < all groups at *p < 0.05) and at 60-min (THC-INH < CON-INJ and THC-INJ at *p < 0.05), whereas THC-INJ resulted in delayed hypothermia at 90-min (THC-INJ < CON-INJ and THC-INH at *p < 0.05) and at 240-min (THC-INJ < all groups at **p < 0.01). (B) Female temperature: data are presented as mean ± SEM; n = 5–6 for each group. Presence of (*) with a solid and dashed green line indicates that THC-INH and THC-INJ respectively differ from one or more other groups. THC-INH resulted in immediate hypothermia at 30-min (THC-INH < all groups at **p < 0.01) and at 60-min (THC-INH < all groups at *p < 0.05), whereas THC-INJ resulted in delayed hypothermia at 90-min (THC-INJ < all groups at *p < 0.05) and at 240-min (THC-INJ < CON-INJ and THC-INH at **p < 0.01).

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