Table 2 Results from cosinor analyses of nucleosides urinary excretion in St 1.

From: Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer

 

1-methylinosine

pseudouridine

1-methylguanosine

1-methyladenosine

N2-N2-dimethylguanosine

adenosine

cytidine

4-acetylcytidine

Number of patients

29

29

29

29

28

28

28

26

Number of patients with significant rhythmicity pattern

7

11

10

10

9

9

10

6

Mesor (µg/g creatinine)

2.41 (0.99–4.67)

66.1 (33.8–97.9)

7.44 (1.97–15.04)

6.57 (0.86–9.18)

6.70 (2.19–12.11)

0.69 (0.18–1.41)

0.61 (0.26–1.13)

3.09 (0.31–5.80)

2.32 [1.90, 2.63]

64.3 [53.6, 80.2]

7.22 [1.97, 9.08]

6.84 [5.27, 7.95]

6.35 [5.16, 8.31]

0.69 [0.51, 0.91]

0.58 [0.44, 0.72]

3.11 [2.46, 3.73]

Amplitude (µg/g creatinine)

0.98 (0.21–2.95)

26.9 (5.74–60.7)

5.57 (1.02–16.36)

1.94 (0.66–4.69)

5.63 (0.38–21.48)

0.39 (0.08–1.24)

0.36 (0.13–0.81)

2.28 (0.29–7.30)

0.71 [0.46, 1.31]

26.7 [16.3, 34.7]

5.24 [3.21, 7.28]

1.76 [0.66, 4.69]

4.74 [2.75, 6.55]

0.24 [0.16, 0.53]

0.28 [0.20, 0.52]

1.49 [0.85, 3.18]

Relative amplitude (% mesor)

0.40 (0.09–1.26)

0.42 (0.06–0.99)

0.80 (0.17–2.07)

0.31 (0.15–0.76)

0.79 (0.07–2.59)

0.69 (0.12–3.11)

0.59 (0.24–1.07)

0.73 (0.12–2.51)

0.33 [0.23, 0.48]

0.41 0.25 0.54]

0.72 [0.59, 1.00]

0.28 [0.20, 0.38]

0.71 [0.49, 1.01]

0.41 [0.31, 0.68]

0.58 [0.43, 0.72]

0.66 [0.32, 0.95]

Acrophase (clock hours and min.)

08:26 (00:06–23:18)

13:06 (01:30–23:42)

13:00 (00:06–23:42)

10:08 (00:01–23:36)

11:13 (00:00–23:30)

10:44 (00:24–23:36)

11:39 (00:06–23:48)

13:30 (00:06–23:54)

06:42 [02:36, 12:24]

12:54 [09:06, 19:00]

12:00 [7:42, 19:18]

9:48 [04:18, 14:42]

10:24 [05:88, 19:01]

10:27 [05:42, 12:48]

12:27 [05:20, 17:50]

13:06 [06:45, 20:48]

  1. For each parameter, i.e. Mesor, Amplitude, Relative amplitude and Acrophase, mean values and (ranges) are reported in upper rows, and median values and [1st, 3rd] quartiles are given in lower rows, using imputed rhythm parameter values from each individual patient.
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