Figure 6
The ovaries and testes of adult Snf5 CKO mice. (A) Representative photos of the ovaries of 6-week-old Snf5 CKO mice. (B) Ratios of ovary weight per body weight in 6-week-old mice. The ratios were significantly lower in female Snf5 CKO mice (*P < 0.05, Student’s t-test). The values from individual mice and the mean ± standard deviation are shown. (C) Histology of the ovaries from 4-month-old, infertile and fertile Snf5 CKO females. The sections were stained with hematoxylin and picric methyl blue. Bars: 100 µm. (D) The number of follicles per ovary. The number of all the stages of follicles was significantly lower in the Snf5 CKO females (*P < 0.05, **P < 0.005, ***P < 0.00005, Student’s t-test). The values from individual mice and the mean ± standard deviation are shown. Open and closed diamonds represent fertile and infertile mice, respectively. (E) Representative photos of the testes of 6-week-old Snf5 CKO mice. (F) Ratios of testis weight per body weight in 2-week-old, 6-week-old and 4-month-old mice. The ratios were significantly lower in male Snf5 CKO mice (*P < 5.0 × 10−5, **P < 0.0005, Student’s t-test). The values from individual mice and the mean ± standard deviation are shown. (G) Histology of the testes of 6-week-old, Snf5 CKO males showing severe and mild phenotypes. Nuclei are counterstained with DAPI. Lower photos represent the higher magnification views of the enclosed areas. Bars: 300 µm.
