Figure 3 | Scientific Reports

Figure 3

From: Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice

Figure 3

O304 treatment induces chromatin remodelling in pancreatic islets of HFD mice. (a) Heatmaps of read distribution in a ± 10 kb window of called ChIP-seq peaks for H3K27Ac and H3K27Me3 in islets from RD control mice. Colorbar below heatmaps indicate ChIP-seq read count. (b,c) Upper panel: heatmaps of read distribution in a ± 3 kb window for (b) H3K27Ac and (c) H3K27Me3 ChIP-seq peaks. Lower panel: density plots of read distribution across ChIP-seq peaks displayed in the heatmaps. (d) Venn diagram showing the overlap of H3K27Ac (left) and H3K27Me3 (right) peaks for RD, HFD, and HFD-O304 islets. (FDR < 0.01).

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