Figure 1 | Scientific Reports

Figure 1

From: Offline low-frequency rTMS of the primary and premotor cortices does not impact motor sequence memory consolidation despite modulation of corticospinal excitability

Figure 1

Experimental design. At the onset of the experiment, 20 motor evoked potentials (MEPs) of the right abductor pollicis brevis muscle (APB) were evoked at 0.1 Hz with the stimulator output set to an individually adjusted intensity to elicit MEPs of ~ 1 mV (MEPpre). This baseline assessment of corticospinal excitability (CSE) was followed by 14 blocks of task training with the right hand (TRAINING). Immediately after termination of TRAINING, participants received low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) of either the left primary motor cortex (M1 rTMS), the dorsal premotor cortex (dPMC rTMS), or SHAM rTMS. 20 MEPs from the APB were again recorded (MEPpost) with the same individually adjusted stimulator output level as during the MEPpre assessment. Participants were retested on task performance (14 blocks) after an interval of 8 h (RETEST).

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