Figure 5 | Scientific Reports

Figure 5

From: Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation

Figure 5

Pathway enrichment analysis for biological and physiological pathways that are up-regulated in the heart primordium after heartbeat initiation. (A) Top 10 pathways assessed by pathway enrichment analysis for biological and physiological pathways that were up-regulated by 1.5 fold or more in the post-heartbeat group compared with those in the pre-heartbeat group. (B) Individual values of relative gene expression of enzymes in glycolysis that are included in the pathway of “Glycolysis and Gluconeogenesis” in the pre- and post-heartbeat groups. Hk1 = Hexokinase-1, Hk2 = Hexokinase-2, Gck = Glucokinase, Gpi = Glucose-6-phosphate isomerase, Pfkm = 6-phosphofructokinase muscle type, Pfkl = 6-phosphofructokinase liver type, Pfkp = 6-phosphofructokinase platelet type, Aldoa = Aldolase A, Aldob = Aldolase B, Aldoc = Aldolase C, Gapdh = Glyceraldehyde-3-phosphate dehydrogenase, Pgk1 = Phosphoglycerate kinase 1, Pgam1 = Phosphoglycerate mutase 1, Pgam2 = Phosphoglycerate Mutase 2, Eno1 = Enolase 1, Eno2 = Enolase 2, Eno3 = Enolase 3, Pkm2 = Pyruvate kinase M2, Pklr = Pyruvate kinase L/R, Ldha = Lactate dehydrogenase A, Ldhb = Lactate Dehydrogenase B.

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