Figure 1
From: Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis
Azan staining of atrial and diseased ventricular tissue. Cardiomyocytes (CMs) are stained orange to pink; connective tissue is visualized in blue. (a) Atrium with endocardial tissue surrounding islets of myocardial tissue. Myocardial tissue is interspersed with interstitial tissue. (b) Hypertrophic myocardium containing enlarged CMs (cell diameter approx. 35 µm) and scant interstitial tissue without additional signs for decompensation. (c) Severe contraction banding. (d) Atrophic CMs. (e) Replacement fibrosis. (f) Interstitial fibrosis. (g) Perivascular fibrosis. Thin blue arrow: interstitial tissue, thin orange arrow: CMs (longitudinal section is marked perpendicular; cross-section is marked horizontal), thin red arrow: arterioles, black arrows: normal cross striations, thin green arrows: myofibroblasts, thick purple arrow: pericardium, asterix: cavity, thick orange arrow: contraction banding, thick green arrow: atrophic CMs, thick blue arrow: fibrosis. Dotted line surrounds altered areas. Endocardium (thick blue arrow), CMs (thick orange arrow, cross section horizontal, longitudinal perpendicular), Enlarged cell diameter (black line), Cavity (Asterix), Interstitial tissue (blue arrow), Fibrotic area (Black arrow), Myofibroblasts (black arrowheads), Arterioles (red arrowhead).
