Figure 7 | Scientific Reports

Figure 7

From: Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

Figure 7

Osteonecrosis induced by tooth extraction and zoledronate administration is significantly blocked by antibacterial drugs. (a) Experimental protocol. (b) Amoxicillin Hydrate, an antibacterial drug, or normal drinking water was administered orally a day before and 6 weeks after surgery for a total of 6 weeks and 1 day. Six weeks after extraction, alveolar bone sections from the mandible were prepared and stained with HE, and the proportion of empty lacunae among all lacunae was calculated. Scale bars = 100 (upper) or 20 μm (lower) panels. Data shows mean percentage (%) of empty lacunae ± SD (n = 5 each, ***P < 0.001, by a Mann–Whitney test). Representative data are shown of at least two independent and identical experiments, each with n = 5.

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