Figure 2
From: Regulation of gene expression by the APP family in the adult cerebral cortex
Significant changes in the transcriptome profile of the cerebral cortex by loss of APP family in the excitatory neurons. (a–c) Multi-dimensional scaling (MDS) plots of the RNA-seq data from all 20 samples (a), the neocortex (b), and hippocampus samples (c). n = 5 mice per genotype. (d,e) MA plots showing the (log2) normalized mean of all genes expressed across the control samples plotted against the neocortex (d) or hippocampus (e) of cTKO mice at the age of 3 months. The upregulated genes (p-value < 0.05) are shown in red, and the downregulated genes (p-value < 0.05) are shown in blue. (f,g) The relative RNA expression levels of all significant DEGs (FDR p-value < 0.05) in the neocortex (f) or hippocampus (g) between controls and cTKO mice were calculated as z-scores and displayed in heatmaps. The color scale of the z-scores’ (− 2, yellow, to + 2, red) is shown between the panels. (h,i) Venn diagrams show the overlaps among the up- or down-regulated DEGs in the neocortex (h) and hippocampus (i) between the controls and cTKO mice.
