Table 1 Demographic and clinical characteristics of the study cohort.

From: Breath biomarkers of insulin resistance in pre-diabetic Hispanic adolescents with obesity

 

Borderline (N = 7±)

HOMA-IR 2.60–3.80

Insulin resistance (N = 15)

HOMA-IR > 3.80

Normal (N = 6)

HOMA-IR < 2.60

Total (N = 28)

p value#

BMI (% of the 95th Percentile)

    

< 0.001

131.14 (12.33)

145.20 (21.69)

127.83 (16.57)

137.96 (20.15)

 

Cholesterol

    

0.951

162.00 (20.74)

160.66 (28.40)

159.16 (48.11)

160.67 (31.84)

 

LDL

    

0.137

114.14 (22.38)

107.333 (23.177)

99.83 (33.59)

107.42 (25.79)

 

HDL

    

< 0.001

36.614 (5.287)

43.82 (6.05)

49.81 (20.25)

43.30 (11.48)

 

Triglycerides

    

0.13

107.42 (34.26)

115.26 (79.19)

85.00 (21.10)

106.82 (62.07)

 

Glucose (mg/dL)

    

< 0.001

86.28 (7.27)

96.73 (16.44)

83.66 (5.58)

91.32 (14.07)

 

Insulin mU/L

    

< 0.001

14.87 (1.56)

29.32 (12.72)

10.56 (1.84)

21.68 (12.54)

 

Glucose/insulin ratio

    

< 0.001

0.32 (0.05)

0.20 (0.05)

0.45 (0.10)

0.28 (0.12)

 

¥HOMA-IR

    

< 0.001

3.16 (0.39)

7.40 (5.16)

2.16 (0.33)

5.22 (4.46)

 

FIRI

    

< 0.001

0.23 (0.03)

0.14 (0.03)

0.32 (0.07)

0.20 (0.08)

 

A1C

    

0.008

5.00 (0.26)

5.30 (0.59)

5.06 (0.17)

5.17 (0.47)

 

AST

    

< 0.001

20.00 (9.09)

31.46 (17.38)

21.00 (4.71)

26.59 (14.80)

 

ALT

    

< 0.001

24.66 (16.27)

50.40 (32.80)

24.83 (9.94)

39.00 (28.90)

 

CRP

    

0.068

0.65 (0.69)

0.78 (0.94)

0.29 (0.30)

0.65 (0.80)

 

Sex

    

0.559

F

2 (28.6%)

6 (40.0%)

2 (33.3%)

10 (35.7%)

 

M

5 (71.4%)

9 (60.0%)

4 (66.7%)

18 (64.3%)

 
  1. The HOMA-IR cut-offs, are based on a study in a Hispanic population22. Data are presented as mean and standard deviation (SD).
  2. ±Each participant provided 4 technical replicate samples for the analysis.
  3. #P-value is calculated by Chi-square test of multiple groups.
  4. ¥Homeostatic model assessment of insulin resistance (HOMA-IR) is calculated by the formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5.
  5. Fasting insulin resistance index (FIRI) is calculated by the formula: (fasting glucose × fasting insulin)/25.