Table 1 AQP4 peptide list. Peptides with a length of 20 amino acids constituting AQP4 molecule (323 amino acids in length) was listed as overlapping by 10 amino acids.

From: High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

Peptides

Amino acid sequences

Immunodominance

References

p1–20

MSDRPTARRWGKCGPLCTRE

–

 

p11–30

GKCGPLCTRENIMVAFKGVW

+

1,3,5

p21–40

NIMVAFKGVWTQAFWKAVTA

–

 

p31–50

TQAFWKAVTAEFLAMLIFVL

–

 

p41–60

EFLAMLIFVLLSLGSTINWG

–

 

p51–70

LSLGSTINWGGTEKPLPVDM

–

 

p61–80

GTEKPLPVDMVLISLCFGLS

+

1,3,5

p71–90

VLISLCFGLSIATMVQCFGH

–

 

p81–100

IATMVQCFGHISGGHINPAV

–

 

p91–110

ISGGHINPAVTVAMVCTRKI

+

3,5

p101–120

TVAMVCTRKISIAKSVFYIA

–

 

p111–130

SIAKSVFYIAAQCLGAIIGA

–

 

p121–140

AQCLGAIIGAGILYLVTPPS

–

 

p131–150

GILYLVTPPSVVGGLGVTMV

+

1,2,4

p141–160

VVGGLGVTMVHGNLTAGHGL

–

 

p151–170

HGNLTAGHGLLVELIITFQL

–

 

p161–180

LVELIITFQLVFTIFASCDS

–

 

p171–190

VFTIFASCDSKRTDVTGSIA

–

 

p181–200

KRTDVTGSIALAIGFSVAIG

–

 

p191–210

LAIGFSVAIGHLFAINYTGA

–

 

p201–220

HLFAINYTGASMNPARSFGP

+

2,3,4

p211–230

SMNPARSFGPAVIMGNWENH

+

1,3,4,5

p221–240

AVIMGNWENHWIYWVGPIIG

–

 

p231–250

WIYWVGPIIGAVLAGGLYEY

–

 

p241–260

AVLAGGLYEYVFCPDVEFKR

–

 

p251–270

VFCPDVEFKRRFKEAFSKAA

–

 

p261–280

RFKEAFSKAAQQTKGSYMEV

+

1,4

p271–290

QQTKGSYMEVEDNRSQVETD

–

 

p281–300

EDNRSQVETDDLILKPGVVH

–

 

p291–310

DLILKPGVVHVIDVDRGEEK

–

 

p301–320

VIDVDRGEEKKGKDQSGEVL

–

 
  1. AQP4 amino acid sequence of the molecules refers to the UniProt database (AQP4_HUMAN P55087-1). The immunodominant AQP4 peptides are shown in bold type.
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