Table 1 The expression levels of the 15 candidate biomarkers in breast cancer tissues and normal, estimated by quantibody array.

From: Identification and validation of plasma biomarkers for diagnosis of breast cancer in South Asian women

Protein

Tumour (T)*

Paired normal (PN)*

Apparently normal (AN)*

T versus AN + PN

T versus AN

T versus PN

N = 46

N = 23

N = 6

Two tailed Z-value

P-value

Two tailed Z-value

P-value

Two tailed Z-value

P-value

CFD

1046.56 (3.2–30,702)

3532.03 (255–30,402)

14,116.49 (805–23,058)

 − 2.52

0.0117

 − 1.68

0.093

 − 2.2

0.0278

FGF1

12,083.04 (93–93,527)

21,209.35 (4636–55,748)

31,247.21 (0–89,281)

 − 1.77

0.0767

 − 0.93

0.3524

 − 1.65

0.0989

FGF2

20.66 (0–4332)

2.00 (0–3432)

104.74 (0–1205)

1.63

0.1031

 − 0.42

0.6745

2.09

0.0366

DKK3

2183.52 (0–19,600)

1098.70 (603–12,889)

5647.57 (0–6399)

1.55

0.1211

 − 1.25

0.2113

2.37

0.0178

sFRP3

162.44 (0–15,728)

152.44 (0–6386)

459.12 (0–5619)

 − 0.63

0.5287

 − 1.53

0.126

 − 0.04

0.9681

IGF-I

610.73 (0–2174)

0.00 (0–673)

0.00 (0–78)

1.72

0.0854

1.73

0.0836

1.24

0.215

IL-17B

559.17 (0–3066)

259.81 (0–1297)

31.72 (0–439)

3.9

0.0001

2.11

0.0349

3.62

0.0003

IP-10

58.61 (0–4458)

0.00 (0–21)

0.00 (0–2)

2.47

0.0135

2.38

0.0173

1.83

0.0673

LEP

5.36 (0–315)

6.05 (0–109)

0.00 (0–38)

5.84

 < 0.0001

3.14

0.0017

5.43

 < 0.0001

LOX-1

15.16 (0–58)

5.10 (0–18)

1.40 (0–6)

5.02

 < 0.0001

3.37

0.0008

4.37

 < 0.0001

MIG

373.73 (0–9995)

55.11 (0–288)

0.00 (0–92)

5.45

 < 0.0001

3.68

0.0002

4.73

 < 0.0001

MIP-1d

51.97 (0–326)

9.11 (0–157)

6.39 (0–53)

4.47

 < 0.0001

2.42

0.0155

4.14

 < 0.0001

OPN

5292.97 (0–142,847)

26.28 (0–1424)

0.00 (0–646)

3.82

0.0001

0.29

0.7718

3.22

0.0013

SDC-1

3746.53 (0–21,503)

158.26 (0–780)

215.38 (0–604)

6.27

 < 0.0001

3.44

0.0006

5.8

 < 0.0001

WIF1

43.74 (0–386)

0.59 (0–124)

0.00 (0–39)

-0.01

0.992

1.35

0.177

-0.62

0.5353

  1. *The concentration of proteins is expressed in pg/ml and the median values along with range (enclosed in parentheses) is tabulated. Unpaired t-test was used to determine the significance of differential protein levels.
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