Figure 3 | Scientific Reports

Figure 3

From: Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models

Figure 3

The merged network is compiled from the top three networks that were most significantly associated with the DEGs, which were either up- or downregulated in at least two individual datasets (Table 3). Upregulated molecules include ARPC5, CACHD1, CACNB4, CHST11, CHST15, CLU, CSF1, CYBRD1, DHX37, FOXF1, FSCN1, HMOX1, KBTBD8, KIF3C, MAP1A, MCAM, OTUB2, PLD1, PODXL, S100A2, SCARB1, SDC1, SLC38A3, SPRY1, STK17A, TGFB2, WNT7A, and ZBTB7C. Downregulated molecules include ARRDC4, AZGP1, CFB, COL3A1, COL6A3, CTNNA3, ENPP2, F3, INAVA, KIZ, LRG1, MACROD1, P3H2, PCDH7, PCOLCE, PPL, PPM1K, RIMKLB, RPS6KA5, RTN2, SERPINH1, SLC7A11, SNCA, SOCS2, TFPI, and TXNIP. Molecular relationship factors were added from the Ingenuity knowledge base comprising ABAT, Actin, Ap1, Ap1 gamma, ARHGEF40, ARRB2, BCAT1, C19orf44, CASC3, CCNB1, CDC42EP3, CEP170, CEPT1, collagen, Collagen type I (complex), Collagen(s), Creb, CYTH3, DHTKD1, F Actin, FARS2, HDL, Hedgehog, HIVEP1, HNRNPL, Integrin, KLHDC2, LDL, LPGAT1, MLXIP, NDUFAF2, NFkB (complex), ORM1, PFKFB4, PHAF1, PIN4, Pld, PORCN, S100A14, SOX1, SOX3, TNFSF15, TNKS, TP53, TRIM65, UBC, Ubiquitin, USP53, VIRMA, and WNT7B. The molecule activity predictor was implemented to display further molecular effects as itemized in the prediction legend.

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