Figure 4

The merged network is compiled from the top three networks that were most significantly associated with the DEGs, which were both up- and downregulated in at least two individual datasets (Table 3). Deregulated molecules comprise AMOT, ANK1, ANTXR2, ANXA2, BCL2L11, BHLHE40, CCN2, CDO1, COL4A1, COL4A2, COL8A1, CXCR4, CYP1B1, DRD2, DUSP5, EMP1, FBLN1, FBN1, FN1, FRAS1, HAS2, HSPA5, IDH2, IGFBP4, IGFBP7, KDM5B, KLHL32, LIPH, LMCD1, LOX, MACROD2, MCM5, MFSD2A, MGP, MTCL1, MYBL2, MYT1, NOSTRIN, NR4A1, NR4A3, P4HA2, PKMYT1, PLAUR, SERPINE1, SLC16A2, SNAP25, SOX2, SPP1, SYNPO, TGFBI, TGFBR2, TGFBR3, TGM2, TKTL1, TNC, TPM2, UPP1, and VEGFA. Molecular relationship factors were added from the Ingenuity knowledge base comprising ADAMTS4, Akt, ASCL2, CCR10, collagen, Collagen type I (complex), Collagen type IV, Collagen(s), Creb, Cyclin A, DUSP8, E2f, Fibrin, Fibrinogen, GABRR1, GML, Histone h3, Histone h4, Hsp70, Hsp90, IFNE, Igf1-Igfbp, Igfbp, Insulin, Integrin, Integrin alpha V beta 3, KLK11, LRP, LRRC4, LURAP1, MAPK3, NAGLU, NFkB (complex), PALD1, POLD4, PPP5C, RNA polymerase II, Rxr, Smad2/3, TENT2, Tgf beta, THTPA, TRPV4, TUBA1A, TUBG2, Vegf, and YY2.