Table 2 Meta-analysis DEG sets compiled from individual datasets of isogenic disease models.

Genes either up- or downregulated

Upregulated genes

ARPC5, BDH1, BDNF, BMP4, CA2, CACHD1, CACNB4, CCDC80, CHST11, CHST15, CLU, CSF1, CYBRD1, DHX37, DPYSL5, EPAS1, EPDR1, FAM189A1, FOXF1, FSCN1, GALNS, GIMAP6, GRK5, HMOX1, KBTBD8, KIF3C, LGR4, MAML2, MANEAL, MAP1A, MCAM, MEST, MYBL1, OTUB2, P3H2, PLD1, PODXL, PRSS23, RCAN1, S100A2, SCARB1, SDC1, SEMA7A, SEPTIN11, SERINC2, SLC38A3, SPRY1, STC1, STK17A, TBC1D4, TGFB2, WNT7A, ZBTB7C, ZGRF1

Downregulated genes

ABCA12, ARRDC4, AZGP1, CACNA2D1, CAPN6, Ccl9, CFB, COL3A1, COL6A3, CRYL1, CTNNA3, Cyp3a13 (related to human CYP3A7),DHDH, DHRS7, ENPP2, F3, FBLIM1, GPC3, GPT2, HERPUD1, IFITM1, IFITM2, INAVA, KIZ, KLHDC1, KRT20, LARP1B, LNCAROD, LONRF2, LRATD2, LRG1, MACROD1, MIA2, MMRN2, NT5DC2, PCDH10, PCDH7, PCOLCE, PDK1, PLEKHH1, PPL, PPM1K, PRPH, PYCR1, RIMKLB, RPS6KA5, RTN2, SERPINH1, SLC7A11, SNCA, SOCS2, SOX2-OT, SPINT1, STRA6, TCAIM, TFPI, TXNIP

Genes both up- and downregulated

ADGRG1, AGPAT5, AMOT, ANK1, ANKRD1, ANTXR2, ANXA2, APOL6, ARMH4, BCL2L11, BHLHE40, CCN2, CDC42EP3, CDO1, CDS1, CELSR2, COL4A1, COL4A2, COL8A1, CTSH, CXCR4, CYP1B1, DNAH2, DRD2, DUSP5, ELFN2, EMP1, EPB41L4B, ERAP1, FBLN1, FBN1, FN1, FRAS1, GCNT1, GPRC5B, HAS2, HDHD2, HIVEP2, HSPA5, IDH2, IGFBP4, IGFBP7, ISG20, KDELR3, KDM5B, KLHL32, LIPH, LMCD1, LMNA, LOX, MACROD2, MCM5, MFSD2A, MGP, MTCL1, MYBL2, MYT1, NEBL, NOSTRIN, NR4A1, NR4A3, NRG2, P4HA2, PDLIM3, PER3, PITPNC1, PKMYT1, PLAUR, PLPP2, PRODH, PRSS35, QSOX1, QSOX2, RGMA, SERPINE1, SH3GL3, SLC16A2, SLC1A4, SLC25A28, SLC26A6, SLC2A1, SLC2A12, SNAP25, SOX2, SPP1, SYNPO, TEF, TGFBI, TGFBR2, TGFBR3, TGM2, TKTL1, TNC, TPM2, TRNP1, UPP1, VEGFA, WDR90