Table 1 Calpains and caspases involved in the proteolysis of proteins codified by genes linked to ALS.
Calpain-1* | Calpain-2* | Caspase-3 | Caspase-6 | Caspase-7 | Caspase-8 | |
|---|---|---|---|---|---|---|
TDP-43 | ++++ | +++ | +++ | ++++ | ++++ | +++ |
C9orf72 | ++++ | ++++ | + | ++ | ++ | +++ |
p62/sequestosome-1 | ++++ | ++++ | ++ | ++++ | ++ | ++++ |
Matrin-3 | ++++ | ++++ | ++ | ++++ | ++++ | ++++ |
VCP | +++ | + | − | ++ | − | ++ |
FUS | ++++ | ++++ | ++ | +++ | +++ | +++ |
SOD1 | − | − | − | − | − | − |
Profilin-1 | − | − | − | − | − | − |
