Table 2 Comparison between patients discontinuing infliximab or azathioprine.

From: Discontinuation of Azathioprine could be considered in pediatric patients with Crohn’s disease who have sustained clinical and deep remission

 

IFX withdrawal group

(n = 15)

AZA withdrawal group

(n = 10)

IFX and AZA withdrawal group

(n = 6)

P-value

Sex, male (%)

7 (31.80)

9 (40.90)

6 (27.30)

0.018Chi

At diagnosis

White blood cell count, × 103/μL

7.80 (7.43, 9.71)

9.29 (8.23, 10.72)

8.61 (7.80, 9.19)

0.673 K

Hematocrit, %

35.60 (33.10, 39.10)

35.20 (32.30, 39.10)

40.00 (37.90, 41.70)

0.069 K

ESR, mm/h

53.00 (41.50, 78.0)

63.00 (39.30, 83.50)

25.00 (23.00, 29.30)

0.071 K

C-reactive protein, mg/dL

1.21 (0.64, 7.60)

2.37 (1.84, 3.52)

2.33 (1.10, 3.46)

0.712 K

Albumin, g/dL

3.80 (3.60, 4.30)

3.80 (3.50, 4.30)

4.20 (4.00, 4.40)

0.479 K

PCDAI at diagnosis

40.00 (33.30, 46.30)

35.00 (30.60, 41.90)

35.00 (30.00, 41.00)

0.515 K

SES-CD at diagnosis

16.00 (11.50, 19.50)

18.00 (14.30, 24.00)

13.50 (7.00, 17.80)

0.298 K

At IFX or AZA withdrawal

White blood cell count, × 103/μL

5.52 (4.80, 7.07)

6.11 (5.45, 6.88)

5.67 (5.11, 5.82)

0.830 K

Hematocrit, %

39.40 (37.10, 43.80)

45.40 (44.50, 46.60)

43.20 (42.50, 45.50)

0.174 K

ESR, mm/h

12.00 (4.50, 20.50)

4.50 (2.30, 9.00)

5.00 (2.80, 11.80)

0.243 K

C-reactive protein, mg/dL

0.03 (0.03, 0.08)

0.04 (0.03, 0.04)

0.13 (0.03, 0.36)

0.437 K

Albumin, g/dL

4.50 (4.40, 4.70)

4.70 (4.60, 4.90)

4.50 (4.50, 4.60)

0.196 K

PCDAI at drug withdrawal

0 (0, 0)

0 (0, 0)

0 (0, 0)

0.669 K

SES-CD at drug withdrawal

0 (0, 0.45)

0 (0, 0)

0 (0, 0.25)

0.496 K

  1. Baseline characteristics of subjects who withdrew infliximab or azathioprine were explored with descriptive statistics through frequencies (proportion) for categorical variables or medians (interquartile range[IQR]) for continuous variables.
  2. Chiχ2 test; K Kruskal–Wallis test.
  3. ESR, Erythrocyte sedimentation rate; PCDAI, Pediatric Crohn’s disease activity index; SES-CD, Simple endoscopic score for Crohn’s disease; AZA, azathioprine; IFX, infliximab.
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