Table 4 Test characteristics of the 6-mRNA score in non-COVID-19 and COVID-19 patients using the three-band test report. “Severe in band” is the number of patients with severe viral infection assigned to the corresponding band. “Non-severe in band” is the number of patients with non-severe viral infection assigned to the corresponding band. The “Percent severe in band” is the percentage of patients in the band who had severe outcome. The “In-band” column is the percentage of patients assigned by the classifier to the corresponding band.

Band	Severe in band	Non-severe in band	Percent severe in band (%)	Sensitivity (%)	Specificity (%)	Likelihood ratio	In-band (%)
(a) Non-COVID-19 results. The band thresholds were set using training data and locked
Low risk	12	570	2.0	85	85	0.18	77
Intermediate risk	43	78	36	54	88	4.6	16
High risk	25	26	49	31	96	8.1	6.7
(b) Non-COVID-19 results. The band thresholds were set using the retrospective data
Low risk	2	420	0.47	98	62	0.04	56
Intermediate risk	68	246	22	85	64	2.3	42
High risk	10	8	56	12	99	11	2.4
(c) Prospective COVID-19 results. The band thresholds were set using training data and locked
Low risk	2	18	10	96	38	0.10	21
Intermediate risk	20	28	42	40	40	0.67	50
High risk	28	1	97	56	98	26	30
(d) Prospective COVID-19 results. The band thresholds were set using the prospective data
Low risk	0	12	0	100	26	0.0	12
Intermediate risk	17	32	35	34	32	0.50	51
High risk	33	3	92	66	94	10	37
(e) Retrospective COVID-19 results. The band thresholds were set using training data and locked
Low risk	14	37	27	75	86	0.28	51
Intermediate risk	33	6	85	58	86	4.1	39
High risk	10	0	100	18	100	Inf	10
(f) Retrospective COVID-19 results. The band thresholds were set using the retrospective data
Low risk	1	16	6	98	37	0.047	17
Intermediate risk	14	24	37	25	44	0.44	38
High risk	42	3	93	74	93	11	45

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