Figure 2 | Scientific Reports

Figure 2

From: Pre-clinical activity of the oral DNA-PK inhibitor, peposertib (M3814), combined with radiation in xenograft models of cervical cancer

Figure 2

Xenograft experiments were performed with HeLa cell lines in athymic nude mice. Treatment was started 26 days after HeLa cell implantation. Three groups were investigated: vehicle alone (n = 3), IR alone (n = 4), or M3814 in combination with IR (n = 4). Tumor volume was measured twice weekly. (A) shows mean tumor volume of each group over the course of treatment. (B) shows average tumor volume at treatment endpoint (day 47), t tests were done to compare the treatment groups. (C) shows mouse weights during the course of treatment.

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