Figure 2 | Scientific Reports

Figure 2

From: Pre-clinical activity of the oral DNA-PK inhibitor, peposertib (M3814), combined with radiation in xenograft models of cervical cancer

Figure 2The alternative text for this image may have been generated using AI.

Xenograft experiments were performed with HeLa cell lines in athymic nude mice. Treatment was started 26 days after HeLa cell implantation. Three groups were investigated: vehicle alone (n = 3), IR alone (n = 4), or M3814 in combination with IR (n = 4). Tumor volume was measured twice weekly. (A) shows mean tumor volume of each group over the course of treatment. (B) shows average tumor volume at treatment endpoint (day 47), t tests were done to compare the treatment groups. (C) shows mouse weights during the course of treatment.

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