Figure 1

Timeline of treatment modality, clinical relapses and MRI scans of the longitudinal cohort. Patients included in the longitudinal cohort (N = 33) were scanned at least twice using the same MRI protocol D (72 scans in total: N = 29 had two scans, N = 3 had three scans, and N = 1 had five scans). The radiology reports that were generated in the context of routine clinical follow-up at the University Hospitals Leuven allowed to distinguish between an ‘active’ and ‘stable’ MRI scan at follow-up. Whenever the neuroradiologists mentioned gadolinium enhancement, new lesions or lesions with an increased volume compared to the preceding MRI scan this implied coding of the MRI scan as ‘active’